The bactericidal ability of HBP as well as the heparin-binding ability are related to its strong positive charge. HBP, as a chemotactic substance, can activate monocytes and macrophages, induce vascular leakage and tissue edema. Inactivating HBP blocks endothelial hyperosmocyte hyperpermeability caused by neutrophils. At present, HBP, as an acute phase protein, is an effective biomarker to assess ...
B-type natriuretic peptide (BNP) and N-terminal B-type natriuretic peptide precursor (NT-proBNP) are biomarkers of cardiac function, as well as the preferred biomarkers for the diagnosis and differential diagnosis of heart failure, disease severity and prognosis assessment, and have been recommended as Level I by several clinical practice guidelines. BNP is mainly degraded in large blood ves...
Chemiluminescence immunoassay technology has long been well-known in the field of in vitro diagnostics! These include, direct chemiluminescence, electrochemiluminescence, enzymatic chemiluminescence, indirect chemiluminescence. So many types of luminescence use luminescent agents that are also very different!1. Acridine ester Direct chemiluminescence Acridine ester (AE) is a tricyclic organic...
Infectious diseases are one of the common diseases in the emergency department, and the systemic inflammatory response syndrome caused by infection is the most fundamental pathophysiological change in sepsis. Due to the complexity of the systemic inflammatory response, there are no ideal diagnostic, stratification, prognostic tools, and effective treatment options. A number of studies have demonst...
Major risk factors for cardiovascular disease Hypertension: one of the main controllable risk factors, accounting for 50% of cardiovascular disease morbidity and 20% of deaths, but the awareness rate is only 46.9%, and the blood pressure control rate is even lower to 15.3%. Dyslipidemia: Studies have shown that the awareness, treatment and control rates of dyslipidemia in ≥ 18-year-olds need to...
World Stroke Day is observed on October 29 to underscore the serious nature and high rates of stroke, raise awareness of the prevention and treatment of the condition, and ensure better care and support for survivors. Stroke and platelet function Stroke refers to an acute cerebrovascular disease caused by the sudden rupture of blood vessels in the brain or the sudden interruption of blood flo...
WBC, CRP, and PCT test indicators for judging infection, and they can be elevated to varying degrees when infection occurs, but they are often inconsistent in clinical work, so how should we analyse these inconsistent results? 1. Blood routine WBC and neutrophil ratio can be used to distinguish bacterial infections from non-bacterial infections, but it should be noted that the sensitivity and spec...