After understanding platelet activation function, this article will now introduce the clinical significance of platelet activation. Normal platelet activation and aggregation are necessary defense mechanisms that help with hemostasis and repair of damaged blood vessels. However, excessive activation can lead to thrombotic disorders. Modern clinical research has shown that many diseases, especially cardiovascular and cerebrovascular diseases, are closely related to changes in platelet activation status.
Thrombotic Event Alert
Activation as an Initiating Factor for Thrombus Formation: Association between Elevated CD62P Levels and Increased Thrombotic
Guiding the Prognosis of Thrombotic Diseases/Tumor Diseases/Infectious Diseases
Assessment of Infection Severity and Thrombotic Risk: Evaluation of Platelet-Leukocyte Aggregates
The measurement of platelet-leukocyte aggregates provides an assessment of the cellular immune status in infected patients, with higher values indicating the progression of bacterial or viral infections. When combined with CD measurements, it allows for a comprehensive evaluation of the thrombotic risk in infected patients, with higher values indicating a higher risk.
Guidelines for Anticoagulant/Antiplatelet Therapy
Antiplatelet therapy is a crucial measure for primary and secondary prevention of cardiovascular diseases. However, individual variations in patient response to medications can result in different treatment outcomes and complications. Therefore, assessing an individual's responsiveness to the medication, in order to predict bleeding and thrombotic risks, is vital for developing personalized antiplatelet therapy plans.
Diagnosis of Thrombocytopenia and Prediction of Bleeding Risk
Thrombocytopenic Disorders, such as Bernard-Soulier Syndrome and Platelet Dysfunction, can increase the risk of bleeding. These conditions can be predicted by the reduction or absence of membrane glycoproteins CD41/CD61/CD42a/CD42b, indicating platelet functional defects.
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